Fault diagnosis for uncertain networked systems

Fault diagnosis has been at the forefront of technological developments for several decades. Recent advances in many engineering fields have led to the networked interconnection of various systems. The increased complexity of modern systems leads to a larger number of sources of uncertainty which must be taken into consideration and addressed properly in the design of monitoring and fault diagnosis architectures. This chapter reviews a model-based distributed fault diagnosis approach for uncertain nonlinear large-scale networked systems to specifically address: (a) the presence of measurement noise by devising a filtering scheme for dampening the effect of noise; (b) the modeling of uncertainty by developing an adaptive learning scheme; (c) the uncertainty issues emerging when considering networked systems such as the presence of delays and packet dropouts in the communication networks. The proposed architecture considers in an integrated way the various components of complex distributed systems such as the physical environment, the sensor level, the fault diagnosers, and the communication networks. Finally, some actions taken after the detection of a fault, such as the identification of the fault location and its magnitude or the learning of the fault function, are illustrated

Design, Performance, and Calibration of the CMS Hadron-Outer Calorimeter

The CMS hadron calorimeter is a sampling calorimeter with brass absorber and plastic scintillator tiles with wavelength shifting fibres for carrying the light to the readout device. The barrel hadron calorimeter is complemented with an outer calorimeter to ensure high energy shower containment in the calorimeter. Fabrication, testing and calibration of the outer hadron calorimeter are carried out keeping in mind its importance in the energy measurement of jets in view of linearity and resolution. It will provide a net improvement in missing \et measurements at LHC energies. The outer hadron calorimeter will also be used for the muon trigger in coincidence with other muon chambers in CMS

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder